Biological aging can be slowed through dietary adjustments, supplementation, and physical activity, as demonstrated by the DO-HEALTH study led by Heike Bischoff-Ferrari.
Previous research has confirmed that “reduced calorie intake has a positive effect on the aging process,” but the role of other interventions, such as vitamin D and omega-3 fatty acids, remained unclear. While animal studies have shown potential anti-aging effects of these substances, data on humans were lacking, necessitating large-scale clinical trials.
The DO-HEALTH trial investigated the effects of daily supplementation with 2,000 IU of vitamin D, 1 g of algae-derived omega-3 fatty acids, and strength training for 30 minutes three times per week. Conducted on 777 individuals over 70 years old, the study assessed aging using an epigenetic clock and found that omega-3s slowed biological aging by approximately four months, regardless of participants’ sex, age, or BMI.
A combination of omega-3s, vitamin D, and exercise had an even greater effect, reinforcing earlier findings that these interventions together reduce cancer risk and prevent frailty. Bischoff-Ferrari emphasized that
Despite these promising outcomes, researchers highlight limitations, such as the absence of a universally accepted standard for measuring biological age. The study’s Swiss participant pool also limits its generalizability. Future research aims to include a more diverse population to refine conclusions about these interventions’ effectiveness in different demographics.
