Inflammation in the gut is linked to psoriasis: new research

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New research from Uppsala University reveals hidden inflammation in the small intestine of psoriasis patients, shedding light on their gastrointestinal symptoms and increased risk of Crohn’s disease.

by @freepik

Psoriasis, a chronic inflammatory skin condition, is often accompanied by systemic effects, including pro-inflammatory activity in the gut. According to Maria Lampinen, a researcher at Uppsala University, many psoriasis patients experience “leaky gut,” a condition where intestinal barrier permeability is compromised. This allows harmful substances to pass into the bloodstream, triggering systemic inflammation and potentially worsening psoriasis symptoms.

The study examined 18 psoriasis patients and 15 healthy controls, revealing elevated levels of pro-inflammatory immune cells in the intestinal samples of psoriasis patients. These immune cells were similar to those activated in skin flare-ups. Half of the psoriasis patients also displayed increased intestinal permeability, which correlated with gastrointestinal symptoms such as bloating and abdominal discomfort.

This research highlights a previously underexplored connection between skin and gut inflammation. Lampinen noted that even patients with mild psoriasis exhibited significant intestinal changes, suggesting that systemic inflammation may contribute to developing gastrointestinal diseases, including Crohn’s disease.

Implications for Psoriasis Treatment

The findings underscore the need for a holistic approach to psoriasis treatment that addresses intestinal barrier dysfunction. By targeting gut health, future therapeutic strategies may help prevent psoriasis complications and improve patient quality of life.

Note: Medical statistics provide general insights and may not account for individual variability. Always consult a healthcare professional for personalized medical advice.

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Igor Foliush
In 1998 he graduated from the Lviv Institute of Physical Education Department of physical rehabilitation From 1998 to 2000 he was an intern at the Istituto Di MedicinaDello Sport Di Roma From 2000 to 2007 he worked as a physiotherapist at the Hospital Santa Maria della Stella (Orvieto) In 2007 he returned to Ukraine From 2007 to 2013 worked as a physiotherapist at the private pediatric clinic "Vita Puer" In 2013, he completed his master's degree at the Melitopol Institute of Ecology and Social Technologies In 2014, he founded the "Dr Foliush Massage Centre" where he works to this day

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