Ibuprofen, a widely used non-steroidal anti-inflammatory drug (NSAID) for pain, fever, and inflammation, has been found to exert previously unrecognized effects on liver metabolic processes, with significant differences between men and women.
A study conducted by researchers at the University of California, Davis, demonstrated that ibuprofen affects 34 distinct metabolic pathways in male mice. These pathways are involved in the metabolism of amino acids, hormones, and vitamins. Additionally, the drug increases the production of reactive oxygen species in male livers, potentially leading to oxidative stress and cellular damage.
A critical finding of the study was the differing response of the proteasome—an essential protein degradation system—between genders. This disparity suggests that ibuprofen alters drug metabolism differently in men and women, which may influence both the efficacy and safety of co-administered medications.
The researchers stress the importance of incorporating gender as a factor in drug prescribing practices to enhance the precision of treatment plans. They also caution against excessive use of ibuprofen due to its potential adverse effects on liver health, advocating for personalized approaches to minimize risks associated with this commonly used painkiller.
