New research reveals that regular aerobic exercise can significantly reduce key pathological markers of Alzheimer’s disease, including amyloid plaques, tau tangles, and brain inflammation, offering a promising strategy for preventing this neurodegenerative disorder.
Researchers from the University of Bristol and the Federal University of São Paulo investigated the effects of structured aerobic exercise on the hippocampus, the brain region responsible for memory and learning. In a study published in Brain Research, rodent models showed a 76% reduction in amyloid plaques, a 63% decrease in tau connections, and a 58% drop in iron accumulation. Exercise improved communication between brain cells, restored oligodendrocyte function (cells that support neuronal health), and reduced cell death.
The study also highlighted significant reductions in brain inflammation, ranging from 55% to 68%, depending on the biomarker. Dr Augusto Coppi, the study’s senior author, stated,
The researchers plan clinical trials to validate these findings in humans and explore the role of iron metabolism in Alzheimer’s disease as part of new therapeutic approaches.
These findings underscore the critical role of aerobic exercise in health programs, particularly for an ageing population. Incorporating physical activity into daily routines could slow Alzheimer’s progression, improve quality of life, and reduce the global burden of this disease.
Disclaimer: Statistical information reflects general trends and does not account for individual variability. Consult your healthcare provider for personalized medical advice.
