{"id":6885,"date":"2025-02-14T13:05:34","date_gmt":"2025-02-14T11:05:34","guid":{"rendered":"https:\/\/foliush-igor.com\/?p=6885"},"modified":"2025-02-14T11:33:29","modified_gmt":"2025-02-14T09:33:29","slug":"scientists-discover-key-mechanism-of-intestinal-cell-ageing","status":"publish","type":"post","link":"https:\/\/foliush-igor.com\/en\/scientists-discover-key-mechanism-of-intestinal-cell-ageing\/","title":{"rendered":"Scientists discover key mechanism of intestinal cell ageing"},"content":{"rendered":"<p><span data-preserver-spaces=\"true\">A recent <a href=\"https:\/\/www.news-medical.net\/news\/20250213\/New-insight-into-gut-stem-cell-aging.aspx\">study<\/a> by Takuya Yamamoto and Mei Nakajima-Koyama highlights the importance of balancing interferon-gamma (IFN-\u03b3) and extracellular signal-regulated kinase (ERK\/MAPK) pathways in maintaining intestinal stem cells (ISCs) during ageing.<\/span><\/p>\n<figure id=\"attachment_5149\" aria-describedby=\"caption-attachment-5149\" style=\"width: 1200px\" class=\"wp-caption aligncenter\"><img loading=\"lazy\" decoding=\"async\" class=\"size-full wp-image-5149\" src=\"https:\/\/foliush-igor.com\/wp-content\/uploads\/2024\/11\/1200-800-06-11-24-01-2.webp\" alt=\"\" width=\"1200\" height=\"800\" srcset=\"https:\/\/foliush-igor.com\/wp-content\/uploads\/2024\/11\/1200-800-06-11-24-01-2.webp 1200w, https:\/\/foliush-igor.com\/wp-content\/uploads\/2024\/11\/1200-800-06-11-24-01-2-768x512.webp 768w\" sizes=\"auto, (max-width: 1200px) 100vw, 1200px\" \/><figcaption id=\"caption-attachment-5149\" class=\"wp-caption-text\">by @freepik<\/figcaption><\/figure>\n<p><span data-preserver-spaces=\"true\">A comparative analysis of intestinal tissues from young and old mice revealed that the ISC population remains stable with age. However, while ISCs retain their proliferative capacity, ageing leads to reduced progenitor cell proliferation and increased differentiation into enteroendocrine cells, which regulate metabolism. These findings suggest an adaptive response of the intestine to ageing.<\/span><\/p>\n<p><span data-preserver-spaces=\"true\">Single-cell transcriptome analysis of over 10,000 cells demonstrated significant age-related changes, particularly in enterocyte maturation. The upregulation of metabolic genes accompanied these changes, and researchers identified MHC class II, Ceacam10, and Ly6e as markers of ISC ageing. However, their lack of correlation at the single-cell level suggests complex regulatory interactions.<\/span><\/p>\n<p><span data-preserver-spaces=\"true\">Further in silico modelling and organoid experiments revealed that IFN-\u03b3 activation and ERK\/MAPK inactivation influence intestinal ageing. A combined treatment using IFN-\u03b3 and a MEK inhibitor (iMEK) showed a compensatory effect: iMEK induced ISC dormancy, which IFN-\u03b3 reversed, suggesting these pathways support ISC maintenance while influencing differentiation patterns.<\/span><\/p>\n<p><span data-preserver-spaces=\"true\">The study concludes that IFN-\u03b3 and ERK\/MAPK signalling balance is essential for preserving ISCs during ageing, but this may come at the expense of differentiated cells, impacting metabolism. Restoring this balance to a more youthful state may offer a promising anti-ageing strategy for intestinal health with minimal ISC disruption.<\/span><\/p>\n","protected":false},"excerpt":{"rendered":"<p>A recent study by Takuya Yamamoto and Mei Nakajima-Koyama highlights the importance of balancing interferon-gamma (IFN-\u03b3) and extracellular signal-regulated kinase (ERK\/MAPK) pathways in maintaining intestinal stem cells (ISCs) during ageing. A comparative analysis of intestinal tissues from young and old mice revealed that the ISC population remains stable with age. However, while ISCs retain their [&hellip;]<\/p>\n","protected":false},"author":2,"featured_media":5150,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[152,159],"tags":[],"class_list":{"0":"post-6885","1":"post","2":"type-post","3":"status-publish","4":"format-standard","5":"has-post-thumbnail","7":"category-news-en","8":"category-news-en-2"},"aioseo_notices":[],"_links":{"self":[{"href":"https:\/\/foliush-igor.com\/en\/wp-json\/wp\/v2\/posts\/6885","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/foliush-igor.com\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/foliush-igor.com\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/foliush-igor.com\/en\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/foliush-igor.com\/en\/wp-json\/wp\/v2\/comments?post=6885"}],"version-history":[{"count":0,"href":"https:\/\/foliush-igor.com\/en\/wp-json\/wp\/v2\/posts\/6885\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/foliush-igor.com\/en\/wp-json\/wp\/v2\/media\/5150"}],"wp:attachment":[{"href":"https:\/\/foliush-igor.com\/en\/wp-json\/wp\/v2\/media?parent=6885"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/foliush-igor.com\/en\/wp-json\/wp\/v2\/categories?post=6885"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/foliush-igor.com\/en\/wp-json\/wp\/v2\/tags?post=6885"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}