{"id":6821,"date":"2025-02-12T11:14:32","date_gmt":"2025-02-12T09:14:32","guid":{"rendered":"https:\/\/foliush-igor.com\/efektyvnist-likiv-vid-diabetu-2-typu-zminyuyetsya-z-vikom\/"},"modified":"2025-02-12T11:48:52","modified_gmt":"2025-02-12T09:48:52","slug":"the-effectiveness-of-type-2-diabetes-medicines-varies-with-age","status":"publish","type":"post","link":"https:\/\/foliush-igor.com\/en\/the-effectiveness-of-type-2-diabetes-medicines-varies-with-age\/","title":{"rendered":"The effectiveness of type 2 diabetes medicines varies with age"},"content":{"rendered":"<p>A recent study <a href=\"https:\/\/jamanetwork.com\/journals\/jama\/article-abstract\/2829848\">published<\/a> in the <em>Journal of the American Medical Association<\/em> highlights age-related variations in the effects of SGLT2 inhibitors, GLP-1 receptor agonists, and DPP4 inhibitors on glucose control and cardiovascular outcomes in patients with type 2 diabetes.<\/p>\n<figure id=\"attachment_6529\" aria-describedby=\"caption-attachment-6529\" style=\"width: 600px\" class=\"wp-caption aligncenter\"><img loading=\"lazy\" decoding=\"async\" class=\"size-full wp-image-6529\" src=\"https:\/\/foliush-igor.com\/wp-content\/uploads\/2025\/01\/600-261-31-01-25-01.jpg\" alt=\"\" width=\"600\" height=\"261\" \/><figcaption id=\"caption-attachment-6529\" class=\"wp-caption-text\">by @freepik<\/figcaption><\/figure>\n<p>An analysis of 103 clinical trials led by Peter Hanlon from the University of Glasgow found that the glucose-lowering effect of SGLT2 inhibitors diminishes with age, with an HbA1c reduction of approximately 0.24\u20130.25% less per 30 years. Conversely, GLP-1 receptor agonists were more effective in older patients receiving mono- or dual therapy. DPP4 inhibitors also showed a slight improvement in HbA1c control in older adults when used in dual therapy.<\/p>\n<p>Despite the reduced glucose-lowering effect in older adults, SGLT2 inhibitors provided stronger cardiovascular protection in this group compared to younger patients. In contrast, GLP-1 receptor agonists had a weaker cardioprotective effect in older individuals. The study did not find any gender-based differences in treatment response.<\/p>\n<p>As the authors noted, <em>&#8220;For haemoglobin A1c, the use of SGLT2 inhibitors showed a moderate decrease in efficacy with increasing age. In contrast, reductions in serious adverse cardiovascular events with SGLT2 inhibitors were greater in older adults compared with younger adults.&#8221;<\/em> These findings suggest that treatment strategies for type 2 diabetes should be tailored to age-related metabolic and cardiovascular considerations.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>A recent study published in the Journal of the American Medical Association highlights age-related variations in the effects of SGLT2 inhibitors, GLP-1 receptor agonists, and DPP4 inhibitors on glucose control and cardiovascular outcomes in patients with type 2 diabetes. An analysis of 103 clinical trials led by Peter Hanlon from the University of Glasgow found [&hellip;]<\/p>\n","protected":false},"author":2,"featured_media":6530,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[152],"tags":[],"class_list":{"0":"post-6821","1":"post","2":"type-post","3":"status-publish","4":"format-standard","5":"has-post-thumbnail","7":"category-news-en"},"aioseo_notices":[],"_links":{"self":[{"href":"https:\/\/foliush-igor.com\/en\/wp-json\/wp\/v2\/posts\/6821","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/foliush-igor.com\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/foliush-igor.com\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/foliush-igor.com\/en\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/foliush-igor.com\/en\/wp-json\/wp\/v2\/comments?post=6821"}],"version-history":[{"count":0,"href":"https:\/\/foliush-igor.com\/en\/wp-json\/wp\/v2\/posts\/6821\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/foliush-igor.com\/en\/wp-json\/wp\/v2\/media\/6530"}],"wp:attachment":[{"href":"https:\/\/foliush-igor.com\/en\/wp-json\/wp\/v2\/media?parent=6821"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/foliush-igor.com\/en\/wp-json\/wp\/v2\/categories?post=6821"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/foliush-igor.com\/en\/wp-json\/wp\/v2\/tags?post=6821"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}